The dynamic TrabecuLink Femoral and Tibial Cones are an attractive solution for the cementless restoration of bone defects10 and for providing additional support to the prosthesis if there is bone loss in the proximal tibia. The combination of the dynamic design5,6 of the cones and the biocompatible material Tilastan– E11,12 is ideal for ensuring stable, long-lasting fixation and successful bone regeneration.
The 3-dimensional TrabecuLink structure, with its pore size, porosity and structure depth, also provides an excellent basis for promoting osteoconduction and microvascularization, taking into account the requirements of the structure-covering protein layer (fibronectin - vitronectin - fibrinogen).1,2 TrabecuLink Cones can be used in combination with the long-established LINK Endo-Model knee family in a wide range of sizes and versions. The choice of sizes corresponds to the dimensions of the hinged knee prostheses.
The sequence of images shows a pore in the TrabecuLink structure being filled with tissue under in-vitro cell culture conditions. The fibronectin laid down by human fibroblasts and continually reorganized over a period of eight days is visible as green fibers. Fibronectin is a component of the extracellular matrix that is formed at an early stage of the healing process. It forms a base for the embedding of collagen, which is essential for mineralization of the tissue and ingrowth of bone into the structure. Aside from the accumulation of fibronectin, which increases over time, we can observe a clear contraction of the matrix towards the center of the pore. This contraction mechanism, which is attributable to the cellular forces acting in the tissue, accelerates the rate at which the pore is filled with tissue, compared to layer-by-layer tissue growth.
(Reference: Joly P et al., PLOS One 2013; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073545). Julius Wolff Institute, Charité - Universitätsmedizin Berlin