The LINK FlexiCones are manufactured from titanium alloy.
LINK continues to invest in additive manufacturing.
The 3-dimensional structure is produced in additive manufacturing process.
The optimized pore geometry for effective cell ongrowth for intended second stability.
The sequence of images shows a pore in the TrabecuLink structure being filled with tissue under in-vitro cell culture conditions. The fibronectin laid down by human fibroblasts and continually reorganized over a period of eight days is visible as green fibers. Fibronectin is a component of the extracellular matrix that is formed at an early stage of the healing process. It forms a base for the embedding of collagen, which is essential for mineralization of the tissue and ingrowth of bone into the structure. Aside from the accumulation of fibronectin, which increases over time, we can observe a clear contraction of the matrix towards the center of the pore. This contraction mechanism, which is attributable to the cellular forces acting in the tissue, accelerates the rate at which the pore is filled with tissue, compared to layer-by-layer tissue growth.
(Reference: Joly P et al., PLOS One 2013; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073545). Julius Wolff Institute, Charité - Universitätsmedizin Berlin